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KMID : 0616120220530040202
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Korean Journal of Pharmacognosy
2022 Volume.53 No. 4 p.202 ~ p.206
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Optimization of Extraction Conditions of Salidroside, Hepatoprotective Compound from Acer Tegmentosum
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Yoo Gui-Jae
Choi In-Wook
Choi Sang-Yoon
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Abstract
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Salidroside is a major phenolic glycoside of Acer tegmentosum (Aceraceae) and known to be a hepatoprotective compound. Extraction conditions are one of the most important factors to save time and cost from an economic point of view. For this reason, this study was conducted to optimize the extraction condition for maximum yield of salidroside. For optimization, three extraction factors such as ethanol concentration (%), extraction temperature (℃), and solvent to material ratio (mg/mL) were tested and optimized for maximum yield of salidroside using response surface methodology (RSM). The optimal condition was obtained as an ethanol concentration of 53.4%, an extraction temperature at 67.11℃ and a solvent to material ratio (mg/mL), 195.55 mg/ml. The salidroside yield under optimal conditions was found to be 1.59 mg/g dried samples, which were well-matched with the predicted value of 1.56 mg/g dried samples. These results will provide useful information about optimized extraction conditions for the development of salidroside as hepatoprotective therapeutics.
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KEYWORD
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Acer tegmentosum, Box?Behnken design, Response surface methodology, Salidroside
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